The first TEDx Event in Macedonia was held on 30.10.2010. INet was one of the official sponsors of the conference among other companies who saw the oportunity to share the "Ideas worth spreading". The ceremony took place in the Youth Cultural Center.

12 carefully selected speakers held presentations in four sessions in front of 100 people audience. Whole day event was broadcasted live on the internet.

The selection of speakers was made by a public call for nominations which was released in the form of web application and shared through social networks. The idea was to include speakers with various backgrounds and the final program to cover topics from many areas, bearing in mind the general themes at TED: Technology, entertainment, design, business, science, culture, art and global issues. The two main selection criteria were: the idea that the speaker wants to submit, and the ability to do it in a way characteristic of TED-conference. The selected speakers of TEDxSkopje were university professors, established professionals and talented young people at the beginning of their career. Beside the 12 speakers, each session included additional materials such as recorded speeches from previous TED-events.